Chair of Developmental Biology
Head of the Chair: assoc. prof. Tambet Tõnissoo
Contact details: Vanemuise 46-221; Phone: +372 7375025, +372 7375828, tambet.tonissoo [ät] ut.ee
Research group of Professor Margus Pooga
Contact: Riia 23b-237, Phone +372 737 5049, margus.pooga [ät] ut.ee
Research at the Chair of Developmental Biology focuses on the following areas:
- Role of nucleotide exchange factor RIC-8 in asymmetric cell division
- Transcription factors of GATA family in development of mouse heart
- Expression and function of Wfs-1 gene
- Elucidation of peptide-mediated cellular delivery mechanisms and application for the cellular transduction of nucleic acids and proteins
- Mechanisms of exogenous nucleic acid transport and development of delivery methods
- Molecular mechanisms of turtle’s shell formation initiation and growth
Title of the project:
- Morphogenesis and cellular dynamics
Drosophila melanogaster, epithelial morphogenesis, BMP (bone morphogenetic protein) signaling, Live imaging
In the last several decades work on model organisms has revealed that small numbers of highly conserved signaling molecules are repeatedly utilized in various stages of development across species. Despite the increasing knowledge of the molecular basis of tissue morphogenesis, how the activity of these signaling pathways is translated into changes in cell behavior and how cell shape changes affect developmental signaling remain poorly understood. Since morphogenesis involves dynamic cellular processes, tracking real-time changes in cell shapes must be crucial for further understanding these processes. By using the Drosophila pupal wing, we are elucidating how tissue morphogenesis and dynamic cellular communications are regulated at the subcellular level.
Ngan Vi Tran
- Toddie-Moore, D.J., Montanari, M.P., Vi Tran, N., Brik, E.M., Antson, H., Isaac Salazar-Ciudad, I. and Shimmi, O. (2020). Mechano-chemical feedback leads to competition for BMP signalling during pattern formation. bioRxiv 2020.09.23.309435; doi: https://doi.org/10.1101/2020.09.23.309435.
- Gui, J., Huang, Y., Montanari, M., Toddie-Moore, D., Kikushima, K., Nix, S., Ishimoto, Y. and Shimmi, O. (2019). Coupling between dynamic 3D tissue architecture and BMP morphogen signaling during Drosophila wing morphogenesis. Proc. Natl. Acad. Sci. U.S.A. 116, 4352-4361.
- Gui, J., Huang, Y. and Shimmi, O. (2016). Scribbled Optimizes BMP Signaling through its Receptor Internalization to the Rab5 Endosome and Promote Robust Epithelial Morphogenesis. PLoS Genetics 12(11), e1006424.
- Tauscher, P., Gui, J. and Shimmi, O. (2016). Adaptive protein divergence of BMP ligands takes place under developmental and evolutionary constraints. Development 143, 3742-3750.
- Künnapuu, J., Tauscher, P.M., Tiusane, N., Nguyen, M., Löytynoja, A., Arora, K. and Shimmi, O. (2014). Cleavage of the Drosophila Screw prodomain is critical for a dynamic BMP morphogen gradient in embryogenesis. Dev. Biol. 389, 149-159.
- Matsuda, S., Blanco, J. and Shimmi, O. (2013). A Feed-Forward Loop Coupling Extracellular BMP Transport and Morphogenesis in Drosophila Wing. PLoS Genetics 9(3), e1003403.
- Matsuda, S., Yoshiyama, N., Künnapuu-Vulli, J., Hatakeyama, M. and Shimmi, O. (2013). Dpp/BMP transport mechanism is required for wing venation in the sawfly Athalia rosae. Insect Biochem. Mol. Biol. 43, 466-473.
- Matsuda, S. and Shimmi, O. (2012). Directional transport and active retention of Dpp/BMP create wing vein patterns in Drosophila. Dev. Biol. 366, 153-162.
- Künnapuu, J., Björkgren, I. and Shimmi, O. (2009). The Drosophila DPP signal is produced by cleavage of its proprotein at evolutionary diversified furin-recognition sites. Proc. Natl. Acad. Sci. U.S.A. 106, 8501-8506.